Publications

The following is a select list of publications. These publications can be accessed online at PUBMED

LARAZOTIDE ACETATE (INN-202)

INN-202

Title Author Journal Date PubMed ID
Larazotide Acetate for Persistent Symptoms of Celiac Disease Despite a Gluten- Free Diet: A Randomized Controlled Trial Leffler D.A., et al. Gastroenterology Jun-2015 25683116
Larazotide Acetate Promotes Tight Junction Assembly in
Epithelial Cells
Gopalakrishnan S, et al. Peptides May-2012 22401910
Larazotide Acetate Regulates Epithelial Tight Junctions
in Vitro and in Vivo
Gopalakrishnan S, et al. Peptides May-2012 22401908

CELIAC DISEASE

Title Author Journal Date PubMed ID
Alterations in intestinal permeability Arrieta M.C., et al. Gut Oct-2006 16966705
Mucosal barrier defects in irritable bowel syndrome. Who left the door open? Barbara G Am J Gastroenterol June-2006 16771952
Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases Fasano A., et al. Nat Clin Pract Gastroenterol Hepatol Sep-2005 16265432
Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes Neu J., et al. J Pediatr Gastroenterol Nutr May-2005 15861021
A porous defense: the leaky epithelial barrier in intestinal disease Clayburgh D.R., et al. Lab Invest March-2004 14767487
Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients Secondulfo M., et al. Dig Liver Dis Jan-2004 14971814
Increased intestinal permeability as a cause of fluctuating postprandial blood glucose levels in Type 1 diabetic patients Damci T., et al. Eur J Clin Invest May-2003 12713453
Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function Clemente M.G., et al. Gut Feb-2003 12524403
Intestinal barrier function Baumgart D.C., et al. Curr Opin Clin Nutr Metab Care Nov-2002 12394645
Intestinal permeation and gastrointestinal disease DeMeo M.T., et al. J Clin Gastroenterol Apr-2002 11907349
Abnormal intestinal permeability predicts relapse in inactive Crohn disease Arnott I.D., et al. Scand J Gastroenterol Nov-2000 11145287
Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat Meddings J.B., et al. Am J Physiol Apr-1999 10198339
Title Author Journal Date PubMed ID
Inflammatory bowel disease: is it really just another break in the wall? Weber C.R., et al. Gut Jan-2007 17172583
Evolving knowledge and therapy of inflammatory bowel disease Korzenik J.R., et al. Nat Rev Drug Discov Mar-2006 16518373
Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease Blair S.A., et al. Lab Invest Feb-2006 16402035
Wheat protein-induced proinflammatory T helper 1 bias in mesenteric lymph nodes of young diabetes-prone rats Chakir H., et al. Diabetologia Aug-2005 16003532
Dual sugar gut-permeability testing on blood drop in animal models Katouzian F., et al. Clin Chim Acta Feb-2005 15653114
Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats Watts T., et al. Proc Natl Acad Sci U S A Feb-2005 15710870
Insulin-dependent diabetes and gut dysfunction: the BB rat model Malaisse W.J., et al. Horm Metab Res Sep-2004 15486808
Zonula occludens toxin acts
as an adjuvant through different mucosal routes and induces protective immune responses
Marinaro M., et al. Infect Immun Apr-2003 12654806
Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells Karyekar C.S., et al. J Pharm Sci Feb-2003 12532391
Zonula occludens toxin (Zot) interferes with the induction of nasal tolerance to gliadin Rossi M., et al. Immunology Letters May-2002 11947928
Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat Meddings J.B., et al. Am J Physiol Apr-1999 10198339
Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model Fasano A., et al. J Clin Invest Mar-1997 9077522
Food-induced type 1 diabetes in the BB rat Scott F.W., et al. Diabetes Metab Rev Dec-1996 9013075
Title Author Journal Date PubMed ID
Increased intestinal permeability precedes clinical onset of type 1 diabetes Bosi E., et al. Diabetologia Dec-2006 17028899
Inflammatory bowel disease and the apical junctional complex Bruewer M., et al. Ann N Y Acad Sci Aug-2006 17057204
Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives Sapone A., et al. Diabetes May-2006 16644703
tate of the art: IBD therapy and clinical trials in IBD Isaacs K.L., et al. Inflamm Bowel Dis Nov-2005 16254481
Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease Norris J.M., et al. JAMA May-2005 15900004
Association of celiac disease and intestinal lymphomas and other cancers Catassi C., et al. Gastroenterology Apr-2005 15825131
Clinical features and diagnosis of celiac disease Dewar D.H., et al. Gastroenterology Apr-2005 15825122
Celiac disease in patients with an affected member, type 1 diabetes, iron-deficiency, or osteoporosis? Murray J.A. Gastroenterology Apr-2005 15825127
National Institutes of Health Consensus Development Conference Statement on Celiac Disease, June 28-30, 2004 James S.P. Gastroenterology Apr-2005 15825115
The G.U.T. of gut Bjarnason I., et al. Scand J Gastroenterol Sep-2004 15513377
Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences Loftus E.V. Gastroenterology May-2004 15168363
Timing of initial cereal exposure in infancy and risk of islet autoimmunity Norris J.M., et al. JAMA Oct-2003 14519705
Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies Ziegler A.G., et al. JAMA Oct-2003 14519706
Celiac disease–how to handle a clinical chameleon Fasano A. NEJM Jun-2003 12815143
Title Author Journal Date PubMed ID
A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease Catassi C., et al. Am J Clin Nutr Jan-2007 17209192
Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines Drago S., et al. Scand J Gastroenterol Apr-2006 16635908
Integrating theories of the etiology of Crohn’s disease. On the etiology of Crohn’s disease: questioning the hypotheses. Chamberlin W.M., et al. Med Sci Monit Feb-2006 16449960
Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac Thomas K.E., et al. J Immunol Feb-2006 16456012
Clinical features and diagnosis of celiac disease Dewar D.H., et al. Gastroenterology Apr-2005 15825122
The safe threshold for gluten contamination in gluten-free products. Can trace amounts be accepted in the treatment of coeliac disease? Collin P., et al. Aliment Pharmacol Ther Jun-2004 15191509
Sourdough bread made from wheat and nontoxic flours and started with selected lactobacilli is tolerated in celiac sprue patients Di Cagno R., et al. Appl Environ Microbiol Feb-2004 14766592
Environmental factors in the etiology of type 1 diabetes Akerblom H.K., et al. Am J Med Genet May-2002 12116173
Environmental triggers of type 1 diabetes Couper J.J. J Paediatr Child Health Jun-2001 11474705
Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain Di Pierro M., et al. J Biol Chem Jun-2001 11278543
Current concepts of celiac disease pathogenesis Schuppan D. Gastroenterology Jul-2000 10889174
Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions Fasano A., et al. Proc Natl Acad Sci U S A Jun-1991 2052603
Dietary proteins as environmental modifiers of type 1 diabetes mellitus Lefebvre D.E., et al. Annu Rev Nutr Jun-1905 16848704
Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin Fasano A. Ann N Y Acad Sci Jun-1905 11193578
Title Author Journal Date PubMed ID
Mechanisms of disease: pathogenesis of Crohn’s disease and ulcerative colitis Sartor R.B. Nat Clin Pract Gastroenterol Hepatol Jul-2006 16819502
High prevalence of coeliac disease in siblings of children with type 1 diabetes Sumnik Z., et al. Eur J Pediatr Jan-2005 15480779
Inflammatory bowel disease: a complex group of genetic disorders Hugot J.P. Best Pract Res Clin Gastroenterol Jun-2004 15157820
The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses Vader W., et al. Proc Natl Acad Sci U S A Oct-2003 14530392
The epidemiology and natural history of Crohn’s disease in population-based patient cohorts from North America: a systematic review Loftus E.V., et al. Aliment Pharmacol Ther Jan-2002 11856078
Interplay between genetics and the environment in the development of celiac disease: perspectives for a healthy life Papadopoulos G.K., et al. J Clin Invest Nov-2001 11696566
A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease Ogura Y., et al. Nature May-2001 11385577
Analysis of families at risk for insulin-dependent diabetes mellitus reveals that HLA antigens influence progression to clinical disease Honeyman M.C., et al. Molecular Medicine Jul-1995 8529124
Genetic aspects of intestinal permeability in inflammatory bowel disease Takeuchi K., et al. Novartis Found Symp Jun-1905 15669640
Title Author Journal Date PubMed ID
Mucosal inflammation in celiac disease: interleukin-15 meets transforming growth factor beta-1 Kagnoff M.F. Gastroenterology Mar-2007 17383437
The toxicity of high molecular weight glutenin subunits of wheat to patients with coeliac disease Dewar D.H., et al. Eur J Gastroenterol Hepatol May-2006 16607142
Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease Thomas K.E., et al. J Immunol Feb-2006 16456012
In vitro-deranged intestinal immune response to gliadin in type 1 diabetes Auricchio R., et al. Diabetes Jul-2004 15220190
The molecular basis of celiac disease Koning F. J Mol Recognit Sep-2003 14523946

INN-108

Title Author Journal Date PubMed ID
Inhibition of Clostridium difficile Toxin A–Induced Colitis in Rats by APAZA Mcvey D.C., et al. Dig Dis Sci Mar-2005 15810644
Title Author Journal Date PubMed ID
Synthesis and evaluation of mutual azo prodrug of 5-aminosalicylic acid linked to 2-phenylbenzoxazole-2-yl-5-acetic acid in ulcerative colitis Jilani J.A., et al. Drug Des Devel Ther Jul-2013 23983456
Synthesis of mutual azo prodrugs of anti-inflammatory agents and peptides facilitated by α-aminoisobutyric acid Kennedy D.A., et al. J Org Chemt Dec-2011 22026631
Inflammatory bowel diseasePharmaceutical approaches to colon targeted drug delivery systems Chourasia M.K., et al. J Pharm Pharm Sci Jan-2003 12753729

ULCERATIVE COLITIS

Title Author Journal Date PubMed ID
5-ASA colonic mucosal concentrations resulting from different pharmaceutical formulations in ulcerative colitis D’Inca R., et al. World J Gastroenterol Sep-2013 24039359
Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with ulcerative colitis Frieri G., et al. Gut Sep-2000 10940280
Inflammatory bowel disease Van Rosendaal G.M. CMAJ Jul-1989 2568163

INN-329

Title Author Journal Date PubMed ID
Dynamic pancreatography with secretin-MRCP Tsai L.L., et al. Appl Radiol May-2005 Not Available
Administration of secretin (RG1068) increases the sensitivity of detection of duct abnormalities by magnetic resonance cholangiopancreatography in patients with pancreatitis Sherman S., et al. Gastroenterology Sep-2014 24906040
Title Author Journal Date PubMed ID
Prevention and management of post-endoscopic retrograde cholangiopancreatography complications Kahaleh M., et al. Clin Endosc Sep-2012 22977824
Risk factors for complications after ERCP: a multivariate analysis of 11,497 procedures over 12 years Cotton P.B., et al. Gastrointest Endosc Jul-2009 19286178